A equipe de pesquisa em cardiologia acompanha a implementação de protocolos de atendimento em cardiologia na RDSL e explora os dados obtidos nestes atendimentos, em particular nos casos de fibrilação atrial, insuficiência cardíaca, dor torácica e síncope que chegam às salas de emergência dos hospitais RDSL em todo o Brasil. Também desenvolve projetos sobre amiloidoses, grupo de doenças raras geradas pelo acúmulo de proteínas anormais em tecidos como o do coração, prejudicando sua função.
Além disso, os cientistas do IDOR desenvolvem pesquisas de ponta em imagem cardiovascular, com uso de tecnologias como ressonância magnética, PET-CT e SPECT-CT. As três técnicas são usadas, por exemplo, no acompanhamento de pacientes com complicações cardíacas da doença de Chagas. Neste projeto, os cientistas avaliam a presença de fibrose do miocárdio como fator prognóstico para pacientes que apresentam arritmias, além de observar o impacto da inflamação sobre a saúde cardiovascular dos pacientes.
Pacientes com manifestações cardiológicas da doença de Chagas, em especial a dor torácica associada a alterações de eletrocardiograma, podem ser erroneamente diagnosticados com síndrome coronária aguda. Por isso, a equipe de pesquisa em cardiologia também trabalha com novas modalidades de exames de imagem que permitam o diagnóstico mais preciso dessa condição.
Outros objetos de estudo do grupo são a fibrose cardíaca e o risco cardiovascular em pacientes com doença hepática gordurosa não alcoólica, a disfunção cardíaca gerada pelo uso de medicamentos quimioterápicos, o uso de novos dispositivos, como os desfibriladores implantáveis, e a análise genética de canalopatias – anormalidades genéticas que levam a um risco aumentado de arritmias e morte súbita. A equipe trabalha, ainda, no desenvolvimento de ensaios clínicos envolvendo novas drogas, patrocinados pela indústria farmacêutica.
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