Nossa equipe de neurologistas, psiquiatras, biólogos, psicólogos e outros especialistas estudam o desenvolvimento do sistema nervoso e seu funcionamento em condições normais e patológicas.
A pesquisa em neurociências é um dos carros-chefe do IDOR, desde a sua concepção. Uma das principais vertentes dessa área de pesquisa é o uso de células reprogramadas e organoides cerebrais para estudo do desenvolvimento e de doenças que acometem o sistema nervoso central. Células epiteliais extraídas da urina ou da pele de voluntários são induzidas a voltar ao estágio embrionário de células-tronco, capazes de se transformar em qualquer tecido humano, incluindo células do cérebro. Cultivadas em laboratório, essas células formam organoides cerebrais – também conhecidos como mini-cérebros – que permitem estudar em detalhe o desenvolvimento do sistema nervoso central e, também, o impacto de vírus como Zika e Sars-Cov-2, a manipulação de genes e os efeitos de medicamentos sobre o funcionamento do tecido nervoso.
Outra linha de pesquisa importante desenvolvida pelo IDOR na área neurociência é a de neuroimagem, em particular aplicada ao estudo da plasticidade cerebral, isto é, da capacidade que o cérebro humano tem de se adaptar a situações adversas. A integração entre os resultados de exames de imagens e dados clínicos, genéticos e laboratoriais permite estudar as doenças do sistema nervoso central de forma aprofundada, em três vertentes principais: doenças do neurodesenvolvimento, reabilitação e plasticidade no envelhecimento.
Com uso de exames de ressonância magnética funcional, os pesquisadores conseguem identificar as rotas de conexão entre as diferentes partes do cérebro saudável e em situações patológicas. Entre as condições estudadas estão a disgenesia do corpo caloso, os acidentes vasculares cerebrais e a síndrome do membro fantasma, que pode surgir após uma amputação.
Cientistas do IDOR estudam, ainda, novas técnicas capazes de ajudar pacientes a recuperarem suas funções cerebrais. Uma das técnicas estudadas é o neurofeedback, que usa a ressonância magnética funcional para mostrar aos pacientes sua atividade cerebral e estimulá-los a controlar essa atividade.
O estudo de transtornos de aprendizagem e possíveis intervenções também faz parte do rol de pesquisas do IDOR voltadas à neurociência. Um exemplo é o desenvolvimento de um software que visa auxiliar crianças neurotípicas e com dislexia e outros transtornos no aprendizado da leitura.
No Centro de Neuropsicologia Aplicada (CNA), o IDOR combina pesquisa científica e atendimento clínico, oferecendo serviço de investigação neuropsicológica a crianças, adolescentes e adultos com suspeita de transtornos de aprendizagem e atenção, problemas comportamentais e dificuldades de memória, entre outros. A equipe multidisciplinar do CNA lidera projetos de pesquisa sobre transtorno do déficit de atenção com hiperatividade e doença de Alzheimer.
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Tovar-Moll F, Monteiro M, Andrade J, Bramati IE, Vianna-Barbosa R, Marins T, Rodrigues E, Dantas N, Behrens TE, de Oliveira-Souza R, Moll J, Lent R. Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7843-8. Epub 2014 May 12. PMID: 24821757; PMCID: PMC4040546.
Szczupak D, Liu C, Yen CCC, Choi SH, Meireles F, Victorino C; IRC5 Consortium; Richards L, Lent R, Silva AC, Tovar-Moll F. Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage. 2020 Aug 15;217:116875. Epub 2020 Apr 23. PMID: 32335262; PMCID: PMC7590260.
Moll J, de Oliveira-Souza R, Basilio R, Bramati IE, Gordon B, Rodríguez-Nieto G, Zahn R, Krueger F, Grafman J. Altruistic decisions following penetrating traumatic brain injury. Brain. 2018 May 1;141(5):1558-1569. PMID: 29590314; PMCID: PMC7341482.
de Oliveira-Souza R. Phobia of the Supernatural: A Distinct but Poorly Recognized Specific Phobia With an Adverse Impact on Daily Living. Front Psychiatry. 2018 Nov 16;9:590. PMID: 30505286; PMCID: PMC6250805.
de Oliveira-Souza R, Paranhos T, Moll J, Grafman J. Gender and Hemispheric Asymmetries in Acquired Sociopathy. Front Psychol. 2019 Mar 19;10:346. PMID: 30941065; PMCID: PMC6433972.
de Oliveira-Souza R, Moll J, Zahn R. Moral cognition in neurology. In: Reference Module in Neuroscience and Biobehavioral Psychology. New York, NY: Elsevier, 2020: 1-7
Prado CSC, Lopes PMG, Moll J, DeSalles A, de Oliveira-Souza R. A case of developmental pedophilia unmasked by frontotemporal dementia. Neurocase, 2021; 27 (2): 129-137
Drummond C, Coutinho G, Monteiro MC, Assuncao N, Teldeschi A, de Souza AS, Oliveira N, Bramati I, Sudo FK, Vanderboght B, Brandao CO, Fonseca RP, de Oliveira-Souza R, Moll J, Mattos P, Tovar-Moll F. Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer’s disease spectrum. Aging (Albany NY). 2019 Oct 31;11(20):9188-9208. Epub 2019 Oct 31. PMID: 31682234; PMCID: PMC6834410.
Nazar BP, Bernardes C, Peachey G, Sergeant J, Mattos P, Treasure J. The risk of eating disorders comorbid with attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Int J Eat Disord. 2016 Dec;49(12):1045-1057. doi: 10.1002/eat.22643. Epub 2016 Nov 15. PMID: 27859581.
Faraone SV et al., The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder. Neuroscience and Biobehavioral Reviews. Volume 128, 2021, Pages 789-818, ISSN 0149-7634.
Thompson EM, Destree L, Albertella L, Fontenelle LF. Internet-Based Acceptance and Commitment Therapy: A Transdiagnostic Systematic Review and Meta-Analysis for Mental Health Outcomes. Behav Ther. 2021 Mar;52(2):492-507.
Fontenelle LF, Destrée L, Brierley ME, Thompson EM, Yücel M, Lee R, Albertella L, Chamberlain SR. The place of obsessive-compulsive and related disorders in the compulsive-impulsive spectrum: a cluster-analytic study. CNS Spectr. 2021 Apr 12:1-10.
Fontenelle LF, Albertella L, Brierley ME, Thompson EM, Destrée L, Chamberlain SR, Yücel M. Correlates of obsessive-compulsive and related disorders symptom severity during the COVID-19 pandemic. J Psychiatr Res. 2021 Apr 13:S0022-3956(21)00198-9.
Brierley ME, Thompson EM, Albertella L, Fontenelle LF. Lifestyle interventions in the treatment of Obsessive-Compulsive and Related Disorders: A systematic review. Psychosom Med. 2021 Jul 23.
Yücel M, Lee RSC, Fontenelle LF. A New Consensus Framework for Phenotyping and Treatment Selecting in Addiction and Obsessive-Compulsive-Related Disorders. JAMA Psychiatry. 2021 Jul 1;78(7):699-700.
Brockington, G, Moreira, APG, Busoc, MS, da Silva SG, Altszylerg E, Fischerh R, and Moll J. Storytelling increases oxytocin and positive emotions and decreases cortisol and pain in hospitalized children. Proceedings of the National Academy of Sciences, 118(22):e2018409118, 2021. PMID: 34031240; PMCID: PMC8179166.
Moll, J, de Oliveira-Souza R, Basilio R, Bramati IE, Gordon B, Rodríguez-Nieto G, Zahn R, Krueger F, Grafman J. Altruistic decisions following penetrating traumatic brain injury. Brain 141(5), 1558-1569, 2018.
Moll, Jorge; Krueger, Frank; Zahn, Roland; Pardini, Matteo; de Oliveira-Souza, Ricardo; Grafman, Jordan. Human fronto–mesolimbic networks guide decisions about charitable donation. Proceedings of the National Academy of Sciences 103 (42), 15623-15628, 2006. Epub 2006 Oct 9. PMID: 17030808; PMCID: PMC1622872
Moll, Jorge; de Oliveira-Souza, Ricardo; Eslinger, Paul J.; Bramati, Ivanei E. et al. The neural correlates of moral sensitivity: a functional magnetic resonance imaging investigation of basic and moral emotions. The Journal of Neuroscience, 22 (7), 2730-2736, 2002.
Moll, Jorge; Zahn, Roland; de Oliveira-Souza, Ricardo; Krueger, Frank; Grafman, Jordan. The neural basis of human moral cognition. Nature Reviews Neuroscience 6 (10), 799-809, 2005.
De Felice FG, Tovar-Moll F, Moll J, Munoz DP & Ferreira ST. (2020) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System. Trends in Neuroscience, 43(6):355-357.
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Aβ oligomers. J Clin Invest, 122(4): 1339-1353, 2012. Commentaries in Nat Rev Neurol, Sci Transl Med and J Clin Invest.
Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s β-amyloid oligomers in mice and monkeys. Cell Metab, 18(6): 831-843, 2013. Cover story, Commentary in Cell Metab.
Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Clarke JR, Ribeiro FC, Beckman D, Staniszevski A, Berman HL, Guerra LA, Forny-Germano L, Meier S, Abisambra JF, Wilcock DM, Prado VF, Prado MAM, de Souza JM, Alves-Leon SV, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG. Exercise-linked FNDC5/irisin rescues synapse and memory defects in Alzheimer’s models. Nature Medicine, 25(1):165-175, 2019. Commented in Nature Medicine, Nature Reviews Drug Discovery and Alzforum.
Melo HM, Seixas da Silva GS, Costa B, Clarke JR, Figueiredo CP, Klein WL, Checler F, Velloso LA, Balthazar M, Cintra D, Ferreira ST, De Felice FG*. (2020) Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α. Cell Reports, 30;2180-2194.
Szczupak D, Liu C, Yen CCC, Choi SH, Meireles F, Victorino C; IRC5 Consortium, Richards L, Lent R, Silva AC, Tovar-Moll F. Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies. Neuroimage. 2020 Aug 15;217:116875.
T Marins, EC Rodrigues, T Bortolini, B Melo, J Moll, F Tovar-Moll. Structural and functional connectivity changes in response to short-term neurofeedback training with motor imagery. Neuroimage. 2019;194, 283-290.
Soares de Oliveira-Szejnfeld P, Levine D, Melo AS, Amorim MM, Batista AG, Chimelli L, Tanuri A, Aguiar RS, Malinger G, Ximenes R, Robertson R, Szejnfeld J, Tovar-Moll F. Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally. Radiology. 2016; 1(1), 203-18.
Tovar-Moll F, Monteiro M, Andrade J, Bramati IE, Vianna-Barbosa R, Marins T, Rodrigues E, Dantas N, Behrens TE, de Oliveira-Souza R, et al. Structural and functional brain rewiring clarifies preserved interhemispheric transfer in humans born without the corpus callosum. Proc Natl Acad Sci U S A. 2014; 111(21), 7843-8.
Simões EL, Bramati I, Rodrigues E, Franzoi A, Moll J, Lent R, Tovar-Moll F. Functional expansion of sensorimotor representation and structural reorganization of callosal connections in lower limb amputees. J Neurosci. 2012; 32(9), 3211-20.
Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Blood mononuclear cell proteome suggests integrin and Ras signaling as critical pathways for antidepressant treatment response. Biol Psychiatry. 2014 Oct 1;76(7):e15-7.
Cassoli JS, Brandão-Teles C, G Santana A, H M F Souza G, Martins-de-Souza D. Ion Mobility-Enhanced Data-Independent Acquisitions Enable a Deep Proteomic Landscape of Oligodendrocytes. Proteomics. 2017 Nov;17(21).
Nascimento JM, Saia-Cereda VM, Sartore RC, da Costa RM, Schitine CS,Freitas HR, Murgu M, de Melo Reis RA, Rehen SK, Martins-de-Souza D. Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities. Front Cell Dev Biol. 2019 Nov 28;7:303.
Garcia-Rosa S, Carvalho BS, Guest PC, Steiner J, Martins-de-Souza D. Blood plasma proteomic modulation induced by olanzapine and risperidone in schizophrenia patients. Proteomics. 2020 Jul 30;224:103813.
Falvella ACB, Smith BJ, Silva-Costa LC, Valença AGF, Crunfli F, Zuardi AW, Hallak JE, Crippa JA, de Almeida V, Martins-de-Souza D. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144.
Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Scientific reports 6 (1), 1-13. 2016. PMID: 28008958; PMCID: PMC5180086.
Sampaio GLA, Martins GLS, Paredes BD, Nonaka CKV, da Silva KN, Rossi EA, Dos Santos RR, Soares MBP, Souza BSF. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem Cell Research. Volume 39, August 2019, 101488. Epub 2019 Jun 25. PMID: 31272037.
