Com foco em pesquisas clínicas, a equipe de gastroenterologia do IDOR atua em conjunto com os serviços de gastroenterologia de toda a RDSL (Gastro D’Or) em projetos que buscam novas drogas para doença inflamatória intestinal, enteropatias eosinofílicas, doença celíaca e neoplasias do tubo digestivo.
Como acontece em outras áreas de pesquisa, a gastroenterologia se dedica tanto a projetos próprios quanto à realização de ensaios clínicos patrocinados pela indústria farmacêutica. Os testes clínicos incluem experimentos com novas drogas, pesquisas de reposicionamento de medicamentos já disponíveis no mercado e comparações entre dois ou mais tratamentos disponíveis para uma mesma condição.
Recentemente, o IDOR participou de um estudo sobre eficácia, a longo prazo, de um medicamento contra a doença de Crohn em pacientes graves, que já haviam usado outras terapias. Em outro projeto, a equipe está fazendo um levantamento demográfico do perfil dos pacientes com doença inflamatória intestinal atendidos pela RDSL.
Imbrizi M, Baima JP, Azevedo MFC, Andrade AR, Queiroz NSF, Chebli JMF, Chebli LA, Argollo MC, Sassaki LY, Parra RS, Quaresma AB, Vieira A, Damião AOMC, Moraes ACS, Flores C, Zaltman C, Vilela EG, Morsoletto EM, Gonçalves Filho FA, … Coy CSR. (2022). Second Brazilian Consensus On The Management Of Crohn’s Disease In Adults: A Consensus Of The Brazilian Organization For Crohn’s Disease And Colitis (Gediib). Arquivos De Gastroenterologia, 59, 20–50.
Baima JP, Imbrizi M, Andrade AR, Chebli LA, Argollo MC, Queiroz NSF, Azevedo MFC, Vieira A, Costa MHM, Fróes RSB, Penna FGCE, Quaresma AB, Damião AOMC, Moraes ACS, Santos CHM, Flores C, Zaltman C, Vilela EG, Morsoletto E, … Saad-Hossne R. (2022). Second Brazilian Consensus On The Management Of Ulcerative Colitis In Adults: A Consensus Of The Brazilian Organization For Crohn’s Disease And Colitis (Gediib). Arquivos De Gastroenterologia, 59, 51–84.
da Silva Moraes AC, de Freitas Moraes G, de Araújo ALE, Luiz RR, Elia C, Carneiro AJ, de Souza HSP. Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn’s disease: comparison with magnetic resonance enterography. Intest Res. 2019 Apr;17(2):227-236. Epub 2019 Apr 10. PMID: 30962408; PMCID: PMC6505095.
Vilela EG, Rocha HC, Moraes AC, Santana GO, Parente JM, Sassaki LY, Miszputen SJ, Quaresma AB, Clara APHS, Jesus ACS, Pinto AS, Silva BLPS, Silva BC, Freire CCF, Santos CHM, Brito C, Teixeira EFL, Miranda EF, Zabot GP, … Saad-Hossne, R.. (2020). Inflammatory Bowel Disease Care In Brazil: How It Is Performed, Obstacles And Demands From The Physicians’ Perspective. Arquivos De Gastroenterologia, 57(4), 416–427.
Perin RL, Damião AOMC, Flores C, Ludvig JC, Magro DO, Miranda EF, Moraes AC, Nones RB, Teixeira FV, Zeroncio M, & Kotze PG. (2019). Vedolizumab In The Management Of Inflammatory Bowel Diseases: A Brazilian Observational Multicentric Study. Arquivos De Gastroenterologia, 56(3), 312–317.
Argollo M, Furfaro F, Gilardi D, Roda G, Allocca M, Peyrin-Biroulet L, Danese S. Modulation of sphingosine-1-phosphate in ulcerative colitis. Expert Opin Biol Ther. 2020 Apr;20(4):413-420.
Danese, S., Argollo, M., Le Berre, C., & Peyrin-Biroulet, L. (2019). JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?. Gut, 68(10), 1893-1899.
Argollo, M., Kotze, P. G., Kakkadasam, P., & D’Haens, G. (2020). Optimizing biologic therapy in IBD: how essential is therapeutic drug monitoring?. Nature Reviews Gastroenterology & Hepatology, 17(11), 702-710.
Argollo, M., Gilardi, D., Peyrin-Biroulet, C., Chabot, J. F., Peyrin-Biroulet, L., & Danese, S. (2019). Comorbidities in inflammatory bowel disease: a call for action. The Lancet Gastroenterology & Hepatology, 4(8), 643-654.
Roda G, Chien Ng S, Kotze PG, Argollo M, Panaccione R, Spinelli A, Kaser A, Peyrin-Biroulet L, Danese S. Crohn’s disease (Primer). Nat Rev Dis Primers 6, 22 (2020).
Domene CE. Robotic surgery – a step into the future. Arq Bras Cir Dig. 2014 Nov-Dec;27(4):233. PMID: 25626928; PMCID: PMC4743211.
Volpe P, Domene CE, Santo MA, Cecconello I. Two port video-assisted gastrostomy and jejunostomy: technical simplification and clinical results. Arq Bras Cir Dig. 2015;28(1):57-60. PMID: 25861072; PMCID: PMC4739252.
Zilberstein B, Franciss MY, Genovesi A, Volpe P, Domene CE, Barchi LC. Pioneer Robotic Serra-Doria Operation for Recurrent Achalasia After Heller’s Cardiomyotomy: A “New Quondam” Procedure. J Laparoendosc Adv Surg Tech A. 2017 May;27(5):524-528. Epub 2017 Mar 29. PMID: 28355101.
Amaral MVFD, Guimarães JR, Volpe P, Oliveira FMM, Domene CE, Roll S, Cavazzola LT. Robotic Transversus Abdominis Release (TAR): is it possible to offer minimally invasive surgery for abdominal wall complex defects? Rev Col Bras Cir. 2017 Mar-Apr;44(2):216-219. English, Portuguese. PMID: 28658342.
Dib VRM, Ramos AC, Kawahara NT, Campos JM, Marchesini JC, Galvão-Neto M, Guimarães AGDP, Picanço-Junior AP, Domene CE. Does weight gain, throughout 15 years follow-up after Nissen laparoscopic fundoplication, compromise reflux symptoms control? Arq Bras Cir Dig. 2020;33(1):e1488. Epub 2020 May 18. PMID: 32428135; PMCID: PMC7236326.
Parente DB, Rodrigues RS, Paiva FF, Oliveira Neto JA, Machado-Silva L, Lanzoni V, Campos CF, Eiras-Araujo AL, do Brasil PE, Garteiser P, Gomes MB, de Mello Perez R. Is MR spectroscopy really the best MR-based method for the evaluation of fatty liver in diabetic patients in clinical practice? PLoS One. 2014 Nov 26;9(11):e112574.
Perazzo H, Fernandes FF, Castro Filho EC, Perez RM. Points to be considered when using transient elastography for diagnosis of portal hypertension according to the Baveno’s VI consensus. J Hepatol. 2015 Oct;63(4):1048-9.
Amorim VB, Parente DB, Paiva FF, Oliveira Neto JA, Miranda AA, Moreira CC, Fernandes FF, Campos CFF, Leite NC, Perez RM, Rodrigues RS. Can gadoxetic acid-enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease? World J Hepatol. 2020 Sep 27;12(9):661-671.
Parente DB, Perazzo H, Paiva FF, Campos CFF, Saboya CJ, Pereira SE, Silva FDE, Rodrigues RS, Perez RM. Higher cut-off values of non-invasive methods might be needed to detect moderate-to-severe steatosis in morbid obese patients: a pilot study. Sci Rep. 2020 Sep 14;10(1):15007.
Pozzobon FM, Perazzo H, Bozza FA, Rodrigues RS, de Mello Perez R, Chindamo MC. Liver injury predicts overall mortality in severe COVID-19: a prospective multicenter study in Brazil. Hepatol Int. 2021 Apr;15(2):493-501.
Rapozo DC, Bernardazzi C, de Souza HS. Diet and microbiota in inflammatory bowel disease: The gut in disharmony. World J Gastroenterol. 2017 Mar 28;23(12):2124-2140.
de S B Fróes R, Carvalho ATP, de V Carneiro AJ, de Barros Moreira AMH, Moreira JPL, Luiz RR, de Souza HS. The socio-economic impact of work disability due to inflammatory bowel disease in Brazil. Eur J Health Econ. 2018 Apr;19(3):463-470.
de Souza HSP, Fiocchi C, Iliopoulos D. The IBD interactome: an integrated view of aetiology, pathogenesis and therapy. Nat Rev Gastroenterol Hepatol. 2017 Dec;14(12):739-749.
de Souza HSP, Fiocchi C. Network Medicine: A Mandatory Next Step for Inflammatory Bowel Disease. Inflamm Bowel Dis. 2018 Mar 19;24(4):671-679.
Pêgo B, Martinusso CA, Bernardazzi C, Ribeiro BE, de Araujo Cunha AF, de Souza Mesquita J, Nanini HF, Machado MP, Castelo-Branco MTL, Cavalcanti MG, de Souza HSP. Schistosoma mansoni Coinfection Attenuates Murine Toxoplasma gondii-Induced Crohn’s-Like Ileitis by Preserving the Epithelial Barrier and Downregulating the Inflammatory Response. Front Immunol. 2019 Mar 18;10:442.
